Acromegaly (/ˌækrɵˈmɛɡəli/; from Ancient Greek άκρος akros "extreme" or "extremities" and μεγάλος megalos "large") is a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH) after epiphyseal plate closure at puberty. A number of disorders may increase the pituitary's GH output, although most commonly it involves a GH-producing tumor called pituitary adenoma, derived from a distinct type of cell (somatotrophs).Acromegaly most commonly affects adults in middle age, and can result in severe disfigurement, complicating conditions, and premature death if unchecked.
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